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Christina Applegate reveals the one terrible MS side effect that’s affected her “more than the disease”

Posted on March 4, 2026 By admin No Comments on Christina Applegate reveals the one terrible MS side effect that’s affected her “more than the disease”
Christina Applegate
Credit: Frazer Harrison/Getty Images, Kevin Winter/Getty Images

Christina Applegate opens up about one of the MS side effects she says has affected her “more than the disease” itself.

A landmark study funded by the National Multiple Sclerosis Society found that nearly 1 million people in the U.S. are living with multiple sclerosis, or MS. The disease “causes breakdown of the protective covering of nerves.” This leads to “numbness, weakness, trouble walking, vision changes and other symptoms,” according to the Mayo Clinic.

Symptoms can vary from person to person.

“Some people lose the ability to walk on their own or move at all. Others may have long periods between attacks without any new symptoms, called remission. The course of the disease varies depending on the type of MS,” the Mayo Clinic notes.

Christina Applegate shared her experiences with Multiple sclerosis

Actress Christina Applegate has openly shared her experiences with MS since her diagnosis, speaking candidly about her health struggles to help raise awareness of the condition.

In her new book, “You With the Sad Eyes: A Memoir by Christina Applegate,” she details how MS affected her battle with body dysmorphia. For Applegate, the disease brought a range of struggles—changes to her weight, muscle mass, and eating habits that she says sometimes bothered her more than the disease itself.

“My relationship with food is so much better than it ever was, but it took a long time to improve. When the MS hit, the stability I’d fought so hard for went haywire. I had to take 15 hours of steroid infusions, and immediately everything just went like a f*cking blob,” she explains, according to Tyla.

She adds: “I want to throw up when I think of the pictures that are out there of me. I look sad and embarrassed. Because all I can think is: everyone is staring. Once, people stared at my boobs. But now I knew they were staring not only because I was disabled; they were staring because I was fat, forever an unacceptable fate for women in Hollywood.”

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