During the early 1990s, she balanced indie films and mainstream projects, building a reputation for portraying complex characters. Then life changed. After becoming a mother to her son Mason, who was born with cerebral palsy, she shifted her priorities. Advocacy for disability awareness and inclusive education became central to her life, earning recognition from major organizations.

Professionally, she moved into television, starring as Maya Gallo in Just Shoot Me! for seven seasons and later appearing in series such as NCIS and Veronica Mars. Now 63, San Giacomo lives in California, still active in acting and advocacy. Her story isn’t about stepping away from Hollywood — it’s about redefining success, balancing career, family, and purpose on her own terms.